The Vieux Lab studies RNA modifications and post-transcriptional regulation of gene expression in the context of the oocyte-to-embryo transition to better understand the RNA contribution to oocyte quality and early embryonic viability. Current work in the lab includes 1) cataloguing the expression and function of the terminal nucleotidyl transferases and exonucleases that modulate RNA tail lengths and composition, in C. elegans; 2) developing transcriptome-wide RNA-tailing assays to identify functional targets of TNTs and exonucleases; and 3) characterizing the regulatory mechanisms responsible for orchestrating RNA tail changes during the oocyte-to-embryo transition.
