The Billiar lab works to understand how mechanical forces affect the cells living in the body’s soft tissues. Soft tissues of the body experience forces during exercise (muscles contract and pull on tendons and ligaments) and at rest (blood vessels stretch with each heartbeat, digestive organs stretch and contract during eating). A better understanding of how a cells “feel” forces, interpret these stimuli, and alter their behavior will aid in creating treatments, and even curing, of a number of diseases from heart valve disease to cancer.

Our lab includes and appreciates people of all backgrounds, races, ethnicities, and gender identities and includes postdocs, graduate students, undergraduates, and high school students.

Congrats to Rozanne on her SB3C talk!

Heartfelt congratulations Ph.D. student Rozanne on an excellent talk at SB3C! This past week, she attended the 2023 Summer Biomechanics, Bioengineering, and Biotransport Conference (SB3C 2023) in Colorado, participating in lectures, symposia, and workshops. Bravo Rozanne!

Well done Juanyong on a fantastic presentation at SB3C!

Congrats to Juanyong on an excellent talk at SB3C! He and others traveled to the 2023 Summer Biomechanics, Bioengineering, and Biotransport Conference (SB3C 2023) in Colorado this past week to participate in various events and lectures.  Congratulations Juanyong!

Prof. Kristen Billiar is awarded grant from NIH to further heart valve research

Researcher, professor, and head of the Department of Biomedical Engineering at WPI Kristen Billiar has been given a $429,456 grant from the National Institute of Health. This endowment will support an existing project investigating the behavior of cardiovascular cells on artificial heart valves in response to mechanical stimuli. Building on his previous research involving calcium deposition causing aortic valve failure and mechanical regulation of apoptosis, Billiar hopes to better understand how mechanical forces affect cell movement and growth.

Read the full article here: https://www.wpi.edu/news/wpi-researcher-leads-project-determine-how-stretching-and-blood-flow-impact-engineered-heart-valves

Congrats to Ying on her Biofabrication publication!

Congrats to Ying on publishing her paper in Biofabridation entitled “Reducing retraction in engineered tissues through design of sequential growth factor treatment.” She and colleagues designed TGF-β1 and FGF-2 based growth factor treatments and successfully reduced tissue retraction by 85% and increased the ECM elastic modulus by 260% compared to non-growth factor treated controls without significantly increasing the contractile force. She also mathematically modeled the behavior!  https://doi.org/10.1088/1758-5090/accd24 

Image of title of Biofabricaton journal article

Our new paper!

Our new paper “Hyaluronic Acid Regulates Heart Valve Interstitial Cell Contraction in Fibrin-based Scaffolds” is now available to download for free until December 12th.

To download please click here.

SB3C news

I appreciate being selected to speak about incorporating standards in my biomechanics lab in the Advances in Biomedical Engineering Education session (you can still view on Whova)


Prof. Billiar provided a “Presentation on Poster Making” for the BMES Smart Stage.

It is accessible publicly through the link: https://www.bmes.org/SSSUDrec

Alongside you can find a presentation on “abstract writing” by Dr. Reinhart King and on “presenting” by Dawn Elliot.