Downstream Principles and Techniques

Downstream Training Improve your basic skills in separation and purification of bio-manufactured products with both single-use and stainless equipment. This training includes theoretical background information on cell harvest and clarification, TFF, and chromatography, including column packing. You will also develop a better understanding of the various protein characteristics and how they affect the purification process, how resins are selected, and how a purification process is developed.

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Program Logistics

  • Program Dates: See Training Schedule
  • Registration Deadline: Two weeks prior to program start
  • Time: 8:00am – 4:00pm
  • Location: Biomanufacturing Education & Training Center (BETC) WPI Gateway Park 2, 50 Prescott Street (2nd floor), Worcester MA
  • Cost: $3,900
  • CEU: 2.8
  • There are no academic prerequisites for this program

There are no academic prerequisites for this program

Key Learning Objectives

  • Understand the principles of centrifugation and how cell harvesting and clarification is completed
  • Understand the principles and applications for depth filtration
  • Understand how protein characteristics facilitate the purification process
  • Become familiar with the different types of chromatographic processes and the principles behind each type
  • Identify the components of a chromatography system and their functions
  • Perform column packing and peak evaluation
  • Identify the components of a TFF system and their functions
  • Understand how viruses are inactivated and removed
  • Understand how a purification process is developed

Benefits of this interactive training

  • Increase your knowledge of the operation, maintenance and troubleshooting of centrifuges, filtration systems, TFF systems and Chromatography systems
  • Decrease the number of process excursions and deviations due to operator error
  • Reduce the time required to become a subject matter expert in your field
  • Become cross-trained in purification procedures to diversify your skill set

CUSTOMIZED TRAINING PROGRAMS

Looking to schedule a private course for your employees or colleagues? Our team of subject matter experts will work with your company to develop training specific to the needs of your organization. Contact us to learn more about customized biomanufacturing training programs:
Catherine Bouthillier
Senior Manager, Healthcare Corporate Partnerships
cbouthillier@wpi.edu
(508) 831-4653