Downstream Principles and Techniques

Downstream Training


Improve your basic skills in separation and purification of bio-manufactured products with both single-use and stainless equipment. This hands-on training includes theoretical background information on cell harvest and clarification, TFF, and chromatography, including column packing. You will also develop a better understanding of the various protein characteristics and how they affect the purification process, how resins are selected, and how a purification process is developed.

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Class size is limited to 18 – reserve your seat early!

2020 Program Logistics

  • Program Start:  TBD
  • Registration Deadline: Two weeks prior to program start
  • Time: 8:00 a.m. to 4:00 p.m.
  • Location: Biomanufacturing Education & Training Center (BETC)
    WPI Gateway Park 2, 50 Prescott St (2nd floor), Worcester MA
  • Price: $3,900
  • CEU: 2.8
  • There are no academic prerequisites for this program

Key Learning Objectives

  • Understand the principles of centrifugation and how cell harvesting and clarification is completed
  • Understand the principles and applications for depth filtration
  • Understand how protein characteristics facilitate the purification process
  • Become familiar with the different types of chromatographic processes and the principles behind each type
  • Identify the components of a chromatography system and their functions
  • Perform column packing and peak evaluation
  • Identify the components of a TFF system and their functions
  • Understand how viruses are inactivated and removed
  • Understand how a purification process is developed

Benefits of this interactive training

  • Increase your knowledge of the operation, maintenance and troubleshooting of centrifuges, filtration systems, TFF systems and Chromatography systems
  • Decrease the number of process excursions and deviations due to operator error
  • Reduce the time required to become a subject matter expert in your field
  • Become cross-trained in purification procedures to diversify your skill set